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      <image:title>Research Videos - Acoustofluidic coating of particles and cells</image:title>
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      <image:title>Research Videos - A reliable, programmable acoustofluidic pump powered by oscillating sharp-edge structures</image:title>
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      <image:title>Research Videos - An acoustofluidic micromixer based on oscillating sidewall sharp-edges</image:title>
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      <image:title>Research Videos - An acoustofluidic sputum liquefier</image:title>
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      <image:title>Research Videos - Standing surface acoustic wave (SSAW)-based microfluidic cytometer</image:title>
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    <loc>https://www.fmcostanzo.com/home-1</loc>
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    <lastmod>2017-08-24</lastmod>
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      <image:title>Home - Fig. 1</image:title>
      <image:caption>Configuration of 3D benchmark. The results of the simulation consists in tracking the displacement of the point A(t) in the figure and in determining the hydrodynamic forces acting on rigid obstacle and flexible bar system.</image:caption>
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      <image:title>Home - Fig. 2</image:title>
      <image:caption>Vertical channel containing viscous fluid through which a small incompressible disk is descending: (a) system’s geometry; (b) initial conditions (disk released from rest in a quiescent fluid); (c) detail of mesh of the immersed body. The disk’s terminal velocity is denoted by Ut.</image:caption>
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      <image:title>Home - Fig. 3</image:title>
      <image:caption>Frame from animation showing the motion of a flexible flag as described in the FSI 2 benchmark by Hron and Turek.</image:caption>
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      <image:title>Home - Fig. 3</image:title>
      <image:caption>Numerical prediction of the motion of a flexible tail flapping as fluids moves around it.  This calculation is, which is part of a well-known benchmarking computational suite, was made to show that a new approach to solve fluid-structure interaction problems was indeed accurate and effective.  Fluid-structure interaction is the study of the deformation of structures when they interact with a fluid in contact with them.  The human body is a "gold-mine" of such problems. Here are just a few examples: blood flowing though flexible vasculature, food moving through the stomach and the intestine, brain pulsating while surrounded by cerebrospinal fluid.</image:caption>
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      <image:title>Home - Fig. 2</image:title>
      <image:caption>Numerically predicted particle trajectories in a microacoustofluidic device in response to a high-frequency excitation of the substrate using surface acoustic waves.  This calculation is part of a study to provide accurate engineering tools to design the next generation of diagnostic devices in biomedical applications.  The devices are part of a growing technological trend called "lab-on-a-chip" (). This technology promises the ability to carry out in the palm of a hand a host of biochemical tests that nowadays require a well-equipped laboratory.</image:caption>
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      <image:title>Home - Fig 1</image:title>
      <image:caption>Numerical prediction of the radial component of the velocity of interstitial fluid relative to that of the tissue in response to the peristaltic motion of the wall of a typical penetrating artery in brain.  This calculation is part of a study addressing an important open question in brain physiology: how are toxic metabolites cleared from brain tissue?  When these metabolites accumulate in brain tissue various pathologies arise, including Alzheimer's disease.</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Download CV</image:caption>
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      <image:title>Home - Fig. 3</image:title>
      <image:caption>Ezb Formulation: magnitude of the (a) Lagrangian velocity and (b) Eulerian velocity for a device with dimensions comparable to the acoustic wavelength. The bottom wall is actuated. The Ezbc formulation (results in this figure) yields results that we believe are erroneous. The lines represent the streamlines of the respective velocities. Here the Lagrangian velocity streamlines cross the channel walls, indicating an unphysical mass flow across the channel walls. By contrast, consistent with the boundary conditions imposed in Ezbc formulation, here the Eulerian velocity streamlines do not cross the channel. These results are not supported by experimental evidence reported in Barnkob et al. (2016).</image:caption>
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      <image:title>Home - Fig. 2</image:title>
      <image:caption>ALE Formulation: magnitude of the Lagrangian-mean velocity (a) and of the Eulerian velocity (b) for a device with dimensions comparable to the acoustic wavelength. The bottom wall is actuated. The lines represent the streamlines of the respective velocities. The Lagrangian velocity streamlines do not cross the channel walls, indicating no mass flow across the channel walls, while the Eulerian velocity streamlines cross the channel walls as though there were an outflow across the channel walls.</image:caption>
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      <image:title>Home - Fig. 1</image:title>
      <image:caption>Microfluidic channel in a soft polymer actuated by surface acoustic waves. The surface acoustic waves leak energy into the polymer and microchannel and as a consequence, a pseudo-standing wave field arises. This field leads to acoustic streaming drag forces and radiation forces on suspended microparticles.</image:caption>
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      <image:title>Home - Method of Manufactured Solutions - 3</image:title>
      <image:caption>Convergence rates for the L2-norm of the error at t = 0.02s for a dynamic evolution without stabilization.</image:caption>
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      <image:title>Home - Method of Manufactured Solutions - 2</image:title>
      <image:caption>Magnitude of fluid velocity in a dynamic evolution without stabilization.</image:caption>
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      <image:title>Home - Method of Manufactured Solutions - 1</image:title>
      <image:caption>Magnitude of fluid velocity in a static evolution with stabilization.</image:caption>
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      <image:caption>Texas A&amp;M University</image:caption>
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  <url>
    <loc>https://www.fmcostanzo.com/honors-awards-1</loc>
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    <priority>0.75</priority>
    <lastmod>2017-08-07</lastmod>
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      <image:title>Honors</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:title>Honors</image:title>
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    <loc>https://www.fmcostanzo.com/research</loc>
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    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:title>Research - Fig. 3</image:title>
      <image:caption>Comparison between the nondimensional shear (μ) and effective shear (μeff ) moduli for the Gent Model with λz = 1, I m = 500 and c2 /c1 = 1 , 1, 2.</image:caption>
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      <image:title>Research - Fig. 2</image:title>
      <image:caption>Comparison between the nondimensional shear (μ) and effective shear (μeff) moduli for the Fung model for various values of λz and a = 0.5.</image:caption>
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      <image:title>Research - Fig. 1</image:title>
      <image:caption>Idealized geometry of a vessel like the esophagus or an artery.</image:caption>
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      <image:title>Research</image:title>
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      <image:title>Research - Fig. 3 - Velocity Evolution</image:title>
      <image:caption>A ball released in a fluid container and floating to the top: velocity evolution.</image:caption>
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      <image:title>Research - Fig. 2 - Pressure Evolution</image:title>
      <image:caption>A ball released in a fluid container and floating to the top: pressure evolution.</image:caption>
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      <image:title>Research - Fig. 1 - Key Result</image:title>
      <image:caption>Key result of the paper: The discrete formulation has the same formal energy estimate as the abstract formulation. This result implies that the discrete formulation is stable.  </image:caption>
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      <image:title>Research - Fig. 3</image:title>
      <image:caption>Plots of the velocity vbead in Eqn (20) corresponding to the boundary conditions in (a) eqn (14) and (b) eqn (15). The color map represents the magnitude of vbead whereas the lines are some of the streamlines of the vbead field. The channel dimensions are L = 300 μm (horizontal dimension), H = 600 μm (vertical dimension), α = 15° (sharp edge angle), and h = 200 μm (height of the sharp edge). The wall displacement was only in the  vertical direction with magnitude 1 μm.</image:caption>
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      <image:title>Research - Fig. 2</image:title>
      <image:caption>Experimentally observed trajectories of 1.9 μm diameter fluorescent polystyrene beads in our acoustically oscillated micro-mixer with sharp edges. The geometry of the microchannel is described in Fig. 1(c) except for the fact that here, the tips of the sharp edges are 200 μm from the wall instead of 250 μm. The driven oscilla- tion is harmonic with a frequency equal to 4.75 kHz.</image:caption>
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      <image:title>Research - Fig. 1</image:title>
      <image:caption>(a) Schematic of the device showing a microfluidic channel with sharp-edge structures on its side walls. The channel walls are subjected to a time-harmonic excitation produced by a piezoelectric transducer placed on one side of the channel. (b) Typical micro streaming patterns produced in the fluid occupying the channel as a response to piezoelectric excitation. (c) Typical geometric dimensions of the corrugated channel.</image:caption>
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      <image:title>Research - Fig. 1</image:title>
      <image:caption>Configuration of 3D benchmark. The results of the simulation consists in tracking the displacement of the point A(t) in the figure and in determining the hydrodynamic forces acting on rigid obstacle and flexible bar system.</image:caption>
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      <image:title>Research - Fig. 2</image:title>
      <image:caption>Vertical channel containing viscous fluid through which a small incompressible disk is descending: (a) system’s geometry; (b) initial conditions (disk released from rest in a quiescent fluid); (c) detail of mesh of the immersed body. The disk’s terminal velocity is denoted by Ut.</image:caption>
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      <image:title>Research - Fig. 3</image:title>
      <image:caption>Frame from animation showing the motion of a flexible flag as described in the FSI 2 benchmark by Hron and Turek.</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:title>Research - Fig. 3</image:title>
      <image:caption>Ezb Formulation: magnitude of the (a) Lagrangian velocity and (b) Eulerian velocity for a device with dimensions comparable to the acoustic wavelength. The bottom wall is actuated. The Ezbc formulation (results in this figure) yields results that we believe are erroneous. The lines represent the streamlines of the respective velocities. Here the Lagrangian velocity streamlines cross the channel walls, indicating an unphysical mass flow across the channel walls. By contrast, consistent with the boundary conditions imposed in Ezbc formulation, here the Eulerian velocity streamlines do not cross the channel. These results are not supported by experimental evidence reported in Barnkob et al. (2016).</image:caption>
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      <image:title>Research - Fig. 2</image:title>
      <image:caption>ALE Formulation: magnitude of the Lagrangian-mean velocity (a) and of the Eulerian velocity (b) for a device with dimensions comparable to the acoustic wavelength. The bottom wall is actuated. The lines represent the streamlines of the respective velocities. The Lagrangian velocity streamlines do not cross the channel walls, indicating no mass flow across the channel walls, while the Eulerian velocity streamlines cross the channel walls as though there were an outflow across the channel walls.</image:caption>
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      <image:title>Research - Fig. 1</image:title>
      <image:caption>Microfluidic channel in a soft polymer actuated by surface acoustic waves. The surface acoustic waves leak energy into the polymer and microchannel and as a consequence, a pseudo-standing wave field arises. This field leads to acoustic streaming drag forces and radiation forces on suspended microparticles.</image:caption>
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      <image:title>Research - Method of Manufactured Solutions - 3</image:title>
      <image:caption>Convergence rates for the L2-norm of the error at t = 0.02s for a dynamic evolution without stabilization.</image:caption>
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      <image:title>Research - Method of Manufactured Solutions - 2</image:title>
      <image:caption>Magnitude of fluid velocity in a dynamic evolution without stabilization.</image:caption>
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      <image:title>Research - Method of Manufactured Solutions - 1</image:title>
      <image:caption>Magnitude of fluid velocity in a static evolution with stabilization.</image:caption>
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    <loc>https://www.fmcostanzo.com/teaching</loc>
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      <image:title>Teaching</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:title>Teaching</image:title>
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  <url>
    <loc>https://www.fmcostanzo.com/publications-1</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:title>Books &amp; Parts of Books</image:title>
      <image:caption>Acoustofluidic micromixer from N. Nama, P.-H. Huang, T. J. Huang, and F. Costanzo, ``Investigation of micromixing by acoustically oscillated sharp-edges,'' Biomicrofluidics, 10 (2016), pp. 024124–1–024124–17. DOI: 10.1063/1.4946875; PMID: 27158292; PMCID: PMC4833753.   The details of the theoretical framework are in N. Nama, P.-H. Huang, T. J. Huang, and F. Costanzo, "Investigation of acoustic streaming patterns around oscillating sharp edges," Lab on a Chip, 14 (2014), pp. 2824–2836. DOI: 10.1039/c4lc00191e; PMID: 24903475; PMCID: PMC4096312. A much improved analytical and numerical framework is in N. Nama, T. J. Huang, and F. Costanzo, "Acoustic streaming: A Lagrangian–Eulerian perspective," Journal of Fluid Mechanics, 825 (2017), pp. 600–630. DOI: 10.1017/jfm.2017.338.  </image:caption>
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      <image:title>Books &amp; Parts of Books</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:title>Books &amp; Parts of Books</image:title>
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      <image:title>Books &amp; Parts of Books</image:title>
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    <loc>https://www.fmcostanzo.com/refereed-papers-1</loc>
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    <lastmod>2017-08-24</lastmod>
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      <image:title>Publications</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:title>Publications</image:title>
      <image:caption>Detail of the immersed mesh motion for the FSI 2 Hron &amp; Turek fluid-structure interaction benchmark. Calculation made using the immersed finite element method. Calculation from S. Roy, L. Heltai, and F. Costanzo, "Benchmarking the immersed finite element method for fluid- structure interaction problems," Computer and Mathematics with Applications, 69 (2015), pp. 1167–1188. DOI: 10.1016/j.camwa.2015.03.012.   The the details of numerical foundations of method are in L. Heltai and F. Costanzo, "Variational implementation of immersed finite element methods," Computer Methods in Applied Mechanics and Engineering, 229–232 (2012), pp. 110–127. DOI: 10.1016/j.cma.2012.04.001.  </image:caption>
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      <image:title>Publications</image:title>
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    <loc>https://www.fmcostanzo.com/conference-proceedings-1</loc>
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    <lastmod>2017-08-25</lastmod>
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      <image:title>Conference Proceedings</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599f21ecbe6594169d41665e/1503601152177/ResearchEyeCandy-4.jpg</image:loc>
      <image:title>Conference Proceedings</image:title>
      <image:caption>Numerical prediction of the longitudinal component of the velocity of interstitial fluid flowing through brain tissue in response to the peristaltic motion of the wall of a typical penetrating artery in brain.  The details of the numerical framework used for this calculation are in F. Costanzo and S. T. Miller, "An arbitrary Lagrangian–Eulerian finite element formulation for a poroelasticity problem stemming from mixture theory," Computer Methods in Applied Mechanics and Engineering, 323 (2017), pp. 64–97. DOI: 10.1016/j.cma.2017.05.006.  </image:caption>
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      <image:title>Conference Proceedings</image:title>
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    <loc>https://www.fmcostanzo.com/conference-papers</loc>
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      <image:title>Conference Presentations</image:title>
      <image:caption>Streaming patterns near sharp edges in a miscroacoustofluidic channel.  Among other things, this device configuration can be used a micropump, a micromixer, a microliquefier.   Numerical and experimental details are in (i) N. Nama, P.-H. Huang, T. J. Huang, and F. Costanzo, "Investigation of acoustic streaming patterns around oscillating sharp edges," Lab on a Chip, 14 (2014), pp. 2824–2836. DOI: 10.1039/c4lc00191e; PMID: 24903475; PMCID: PMC4096312; (ii) N. Nama, P.-H. Huang, T. J. Huang, and F. Costanzo, ``Investigation of micromixing by acoustically oscillated sharp-edges,'' Biomicrofluidics, 10 (2016), pp. 024124–1–024124–17. DOI: 10.1063/1.4946875; PMID: 27158292; PMCID: PMC4833753.  </image:caption>
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      <image:title>Conference Presentations</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
    </image:image>
    <image:image>
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      <image:title>Conference Presentations</image:title>
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    <loc>https://www.fmcostanzo.com/service</loc>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/59847477db29d66f8949480a/59847488914e6b93fcd1c4e8/1503606837868/francesco-profile-image.jpg</image:loc>
      <image:title>Profile Picture - w/Email</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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  </url>
  <url>
    <loc>https://www.fmcostanzo.com/profile-picture-name-only</loc>
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    <lastmod>2017-08-24</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599f380615d5dbb47b3f9e5d/1503606790880/</image:loc>
      <image:title>Profile Picture - Basic</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Download CV</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/59847441d482e94a17e8030c/59847460db29d66f894946f7/1503606790880/francesco-profile-image.jpg</image:loc>
      <image:title>Profile Picture - Basic</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Download CV</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/image-collections</loc>
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    <lastmod>2017-08-04</lastmod>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/education-images</loc>
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    <lastmod>2017-08-22</lastmod>
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      <image:title>Education Logos</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/59846dfff9a61e76c6ee7cfa/59846e128419c27e055effde/1503429029545/politecnico-milano.jpg</image:loc>
      <image:title>Education Logos</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/59846dfff9a61e76c6ee7cfa/59846e4c1e5b6c1be8a73169/1503428996481/texas-a-and-m.jpg</image:loc>
      <image:title>Education Logos</image:title>
      <image:caption>Texas A&amp;M University</image:caption>
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  </url>
  <url>
    <loc>https://www.fmcostanzo.com/book-covers</loc>
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    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599f39c7bebafbb13ba1c760/1503607134274/</image:loc>
      <image:title>Book Covers</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5988ad2715d5db25d976f632/5988ad3f914e6bb95b91199a/1503607134274/statics.jpg</image:loc>
      <image:title>Book Covers</image:title>
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      <image:title>Book Covers</image:title>
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      <image:title>Book Covers</image:title>
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  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievements-6</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599ee91ef9a61e79d14e2cf9/1502198378345/</image:loc>
      <image:title>Key Achievements 6</image:title>
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      <image:title>Key Achievements 6</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989ba56bebafbda588fdcc4/599ee8ac4c0dbf3e6afa27d0/1503586541111/KeyAchievements6-1.jpg</image:loc>
      <image:title>Key Achievements 6 - Fig. 1</image:title>
      <image:caption>Idealized geometry of a vessel like the esophagus or an artery.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989ba56bebafbda588fdcc4/599ee8b4ccc5c5e6c8ab6138/1503586567684/KeyAchievements6-2.jpg</image:loc>
      <image:title>Key Achievements 6 - Fig. 2</image:title>
      <image:caption>Comparison between the nondimensional shear (μ) and effective shear (μeff) moduli for the Fung model for various values of λz and a = 0.5.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989ba56bebafbda588fdcc4/599ee8b8d2b85710609ab17d/1503586590807/KeyAchievements6-3.jpg</image:loc>
      <image:title>Key Achievements 6 - Fig. 3</image:title>
      <image:caption>Comparison between the nondimensional shear (μ) and effective shear (μeff ) moduli for the Gent Model with λz = 1, I m = 500 and c2 /c1 = 1 , 1, 2.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievements-2</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599e17364c0dbf1bc7882e82/1502196673687/</image:loc>
      <image:title>Key Achievements 2</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b3a446c3c4603303b967/5989b3bc914e6b1524ba5891/1502196673687/KeyAchievements2-1.jpg</image:loc>
      <image:title>Key Achievements 2</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b3a446c3c4603303b967/599dcaa69f8dce3deaf8f48b/1503532806408/KeyAchievements2-1.jpg</image:loc>
      <image:title>Key Achievements 2 - Fig. 1</image:title>
      <image:caption>Microfluidic channel in a soft polymer actuated by surface acoustic waves. The surface acoustic waves leak energy into the polymer and microchannel and as a consequence, a pseudo-standing wave field arises. This field leads to acoustic streaming drag forces and radiation forces on suspended microparticles.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b3a446c3c4603303b967/599dcaaa579fb34211773af1/1503532835124/KeyAchievements2-2.jpg</image:loc>
      <image:title>Key Achievements 2 - Fig. 2</image:title>
      <image:caption>ALE Formulation: magnitude of the Lagrangian-mean velocity (a) and of the Eulerian velocity (b) for a device with dimensions comparable to the acoustic wavelength. The bottom wall is actuated. The lines represent the streamlines of the respective velocities. The Lagrangian velocity streamlines do not cross the channel walls, indicating no mass flow across the channel walls, while the Eulerian velocity streamlines cross the channel walls as though there were an outflow across the channel walls.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b3a446c3c4603303b967/599dcaadf9a61e30f52e566f/1503532853996/KeyAchievements2-3w.jpg</image:loc>
      <image:title>Key Achievements 2 - Fig. 3</image:title>
      <image:caption>Ezb Formulation: magnitude of the (a) Lagrangian velocity and (b) Eulerian velocity for a device with dimensions comparable to the acoustic wavelength. The bottom wall is actuated. The Ezbc formulation (results in this figure) yields results that we believe are erroneous. The lines represent the streamlines of the respective velocities. Here the Lagrangian velocity streamlines cross the channel walls, indicating an unphysical mass flow across the channel walls. By contrast, consistent with the boundary conditions imposed in Ezbc formulation, here the Eulerian velocity streamlines do not cross the channel. These results are not supported by experimental evidence reported in Barnkob et al. (2016).</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievements-5</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599e2040e9bfdfcc1bc0755a/1502197613253/</image:loc>
      <image:title>Key Achievements 5</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b75a6b8f5b32f3b22238/5989b76ce45a7cfe22b1905c/1502197613253/KeyAchievements5-1.jpg</image:loc>
      <image:title>Key Achievements 5</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b75a6b8f5b32f3b22238/599e1fd7be42d6df90339fa6/1503535126599/KeyAchievements5-1.jpg</image:loc>
      <image:title>Key Achievements 5 - Fig. 1</image:title>
      <image:caption>(a) Schematic of the device showing a microfluidic channel with sharp-edge structures on its side walls. The channel walls are subjected to a time-harmonic excitation produced by a piezoelectric transducer placed on one side of the channel. (b) Typical micro streaming patterns produced in the fluid occupying the channel as a response to piezoelectric excitation. (c) Typical geometric dimensions of the corrugated channel.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b75a6b8f5b32f3b22238/599e1fde37c581435a2ab1b6/1503535149182/KeyAchievements5-2.jpg</image:loc>
      <image:title>Key Achievements 5 - Fig. 2</image:title>
      <image:caption>Experimentally observed trajectories of 1.9 μm diameter fluorescent polystyrene beads in our acoustically oscillated micro-mixer with sharp edges. The geometry of the microchannel is described in Fig. 1(c) except for the fact that here, the tips of the sharp edges are 200 μm from the wall instead of 250 μm. The driven oscilla- tion is harmonic with a frequency equal to 4.75 kHz.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b75a6b8f5b32f3b22238/599e1fe3e45a7c310e02286d/1503535168598/KeyAchievements5-3.jpg</image:loc>
      <image:title>Key Achievements 5 - Fig. 3</image:title>
      <image:caption>Plots of the velocity vbead in Eqn (20) corresponding to the boundary conditions in (a) eqn (14) and (b) eqn (15). The color map represents the magnitude of vbead whereas the lines are some of the streamlines of the vbead field. The channel dimensions are L = 300 μm (horizontal dimension), H = 600 μm (vertical dimension), α = 15° (sharp edge angle), and h = 200 μm (height of the sharp edge). The wall displacement was only in the  vertical direction with magnitude 1 μm.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievements-1</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-23</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599dd998e6f2e1230cd23dbc/1502196422968/</image:loc>
      <image:title>Key Achievements 1</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b29dbe65944f2a3d1cf3/5989b2c5579fb3fb9606878d/1502196422968/KeyAchievements1-1.jpg</image:loc>
      <image:title>Key Achievements 1</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b29dbe65944f2a3d1cf3/599c9d3a8fd4d2fa52d38a11/1503517043353/KeyAchievements1-1.jpg</image:loc>
      <image:title>Key Achievements 1 - Method of Manufactured Solutions - 1</image:title>
      <image:caption>Magnitude of fluid velocity in a static evolution with stabilization.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b29dbe65944f2a3d1cf3/599c9d3a59cc68d05673d40b/1503517056508/KeyAchievements1-2.jpg</image:loc>
      <image:title>Key Achievements 1 - Method of Manufactured Solutions - 2</image:title>
      <image:caption>Magnitude of fluid velocity in a dynamic evolution without stabilization.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b29dbe65944f2a3d1cf3/599c9d3bf43b552f89f5643c/1503517080767/KeyAchievements1-3.png</image:loc>
      <image:title>Key Achievements 1 - Method of Manufactured Solutions - 3</image:title>
      <image:caption>Convergence rates for the L2-norm of the error at t = 0.02s for a dynamic evolution without stabilization.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievements-4</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:title>Key Achievements 4</image:title>
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      <image:title>Key Achievements 4</image:title>
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      <image:title>Key Achievements 4</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b62e86e6c050ffa4aec0/599f27f0be6594169d420cd3/1503603631251/ok_tracks_01_um.gif</image:loc>
      <image:title>Key Achievements 4</image:title>
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      <image:title>Key Achievements 4</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b62e86e6c050ffa4aec0/599f2bcdbe42d6c9ac3f430d/1503603664213/ok_tracks_08_um.gif</image:loc>
      <image:title>Key Achievements 4</image:title>
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      <image:title>Key Achievements 4</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b62e86e6c050ffa4aec0/599f2bd5be42d6c9ac3f43e4/1503603672664/ok_tracks_10_um.gif</image:loc>
      <image:title>Key Achievements 4</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b62e86e6c050ffa4aec0/599f2bdfccc5c51d364466c5/1503603682762/ok_tracks_20_um.gif</image:loc>
      <image:title>Key Achievements 4</image:title>
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  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievements-3</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599e17776a4963803bb3f282/1503532884344/</image:loc>
      <image:title>Key Achievements 3 - Fig. 1</image:title>
      <image:caption>Configuration of 3D benchmark. The results of the simulation consists in tracking the displacement of the point A(t) in the figure and in determining the hydrodynamic forces acting on rigid obstacle and flexible bar system.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b4f903596e41d8c88745/599dcccef14aa1072eb9ee15/1503532884344/KeyAchievements3-1.jpg</image:loc>
      <image:title>Key Achievements 3 - Fig. 1</image:title>
      <image:caption>Configuration of 3D benchmark. The results of the simulation consists in tracking the displacement of the point A(t) in the figure and in determining the hydrodynamic forces acting on rigid obstacle and flexible bar system.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b4f903596e41d8c88745/5989b5204c0dbf9c31494a02/1502197025343/KeyAchievements3-1.jpg</image:loc>
      <image:title>Key Achievements 3</image:title>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b4f903596e41d8c88745/599dcccef7e0abbcaa713df9/1503532901425/KeyAchievements3-2.jpg</image:loc>
      <image:title>Key Achievements 3 - Fig. 2</image:title>
      <image:caption>Vertical channel containing viscous fluid through which a small incompressible disk is descending: (a) system’s geometry; (b) initial conditions (disk released from rest in a quiescent fluid); (c) detail of mesh of the immersed body. The disk’s terminal velocity is denoted by Ut.</image:caption>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/5989b4f903596e41d8c88745/599dcccee9bfdfdf306062a3/1503532919124/KeyAchievements3-3.jpg</image:loc>
      <image:title>Key Achievements 3 - Fig. 3</image:title>
      <image:caption>Frame from animation showing the motion of a flexible flag as described in the FSI 2 benchmark by Hron and Turek.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/key-achievement-1-summary</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-24</lastmod>
    <image:image>
      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/59847477db29d66f8949480a/59847488914e6b93fcd1c4e8/1503606837868/francesco-profile-image.jpg</image:loc>
      <image:title>Key Achievement 1 Details - An Arbitrary Lagrangian–Eulerian FEM Formulation</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599dd7b8579fb34211784b23/1501626336829/msc-evening-image.jpg</image:loc>
      <image:title>Key Achievement 1 Details - An Arbitrary Lagrangian–Eulerian FEM Formulation</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.fmcostanzo.com/research-interests</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2017-08-23</lastmod>
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      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/t/599dde34b8a79ba9c1928bfb/1503518191785/</image:loc>
      <image:title>Research Interests - Fig 1</image:title>
      <image:caption>Numerical prediction of the radial component of the velocity of interstitial fluid relative to that of the tissue in response to the peristaltic motion of the wall of a typical penetrating artery in brain.  This calculation is part of a study addressing an important open question in brain physiology: how are toxic metabolites cleared from brain tissue?  When these metabolites accumulate in brain tissue various pathologies arise, including Alzheimer's disease.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/599dd0c73e00bef256add88f/599dd0d6cd39c3b6a6035948/1503518191785/ResearchInterest-1.jpg</image:loc>
      <image:title>Research Interests - Fig 1</image:title>
      <image:caption>Numerical prediction of the radial component of the velocity of interstitial fluid relative to that of the tissue in response to the peristaltic motion of the wall of a typical penetrating artery in brain.  This calculation is part of a study addressing an important open question in brain physiology: how are toxic metabolites cleared from brain tissue?  When these metabolites accumulate in brain tissue various pathologies arise, including Alzheimer's disease.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://static1.squarespace.com/static/596fe5cbf5e2319b746d6251/599dd0c73e00bef256add88f/599dd0db59cc68c69d2fa19b/1503518246898/ResearchInterest-2.jpg</image:loc>
      <image:title>Research Interests - Fig. 2</image:title>
      <image:caption>Numerically predicted particle trajectories in a microacoustofluidic device in response to a high-frequency excitation of the substrate using surface acoustic waves.  This calculation is part of a study to provide accurate engineering tools to design the next generation of diagnostic devices in biomedical applications.  The devices are part of a growing technological trend called "lab-on-a-chip" (). This technology promises the ability to carry out in the palm of a hand a host of biochemical tests that nowadays require a well-equipped laboratory.</image:caption>
    </image:image>
    <image:image>
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      <image:title>Research Interests - Fig. 3</image:title>
      <image:caption>Numerical prediction of the motion of a flexible tail flapping as fluids moves around it.  This calculation is, which is part of a well-known benchmarking computational suite, was made to show that a new approach to solve fluid-structure interaction problems was indeed accurate and effective.  Fluid-structure interaction is the study of the deformation of structures when they interact with a fluid in contact with them.  The human body is a "gold-mine" of such problems. Here are just a few examples: blood flowing though flexible vasculature, food moving through the stomach and the intestine, brain pulsating while surrounded by cerebrospinal fluid.</image:caption>
    </image:image>
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      <image:title>Research Interests - Details</image:title>
      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:title>Key Achievements 7 - Fig. 1 - Key Result</image:title>
      <image:caption>Key result of the paper: The discrete formulation has the same formal energy estimate as the abstract formulation. This result implies that the discrete formulation is stable.  </image:caption>
    </image:image>
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      <image:caption>Key result of the paper: The discrete formulation has the same formal energy estimate as the abstract formulation. This result implies that the discrete formulation is stable.  </image:caption>
    </image:image>
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      <image:title>Key Achievements 7 - Fig. 2 - Pressure Evolution</image:title>
      <image:caption>A ball released in a fluid container and floating to the top: pressure evolution.</image:caption>
    </image:image>
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      <image:title>Key Achievements 7 - Fig. 3 - Velocity Evolution</image:title>
      <image:caption>A ball released in a fluid container and floating to the top: velocity evolution.</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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      <image:caption>Francesco Costanzo, Ph.D. Email: fmcostanzo@psu.edu Download CV</image:caption>
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